How do vaccines work? Posted on 07/03/2022 (13/05/2022) by joshua How do vaccines work? March 7, 2022 Vaccines generally work through provoking the body into developing and mounting an immune response by imitating an infection. As a result the body produces specialized immune cells and antibodies against the target organisms. The initial exposure (vaccination) also makes the body “remember”” past exposures and thus mount a quicker response in future exposures to the same disease causing agent.